Copper(I) 3-Methylsalicylate Mediates the Chan–Lam N-Arylation of Heterocycles |
| |
| Authors: | Abdelbasset A Farahat |
| |
| Institution: | 1. Department of Chemistry , Georgia State University , Atlanta , Georgia , USA;2. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy , Mansoura University , Mansoura , Egypt |
| |
| Abstract: | Copper(I) 3-methylsalicylate (CuMeSal) mediates N-arylation reactions between aryl boronic acids and aromatic heterocycles (Chan–Lam coupling) under moderate reaction conditions (K2CO3, methanol, 65 °C, in air, 3–5 h). Both electron-rich and electron-deficient aryl boronic acids and a diverse set of N-heterocycles were allowed to react and gave N-arylation products in reasonable yields, which demonstrate the utility of this catalyst. |
| |
| Keywords: | C-N bond formation Chan–Lam coupling copper(I) 3-methylsalicylate N-arylation |
|
|
