Synthesis of Tetrahydrobenzazepinesulfonamides and Their Rearrangement to Diarylsulfones |
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| Authors: | Hui Ren James R McKee |
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| Institution: | 1. Department of Chemistry &2. Biochemistry , University of the Sciences in Philadelphia , Philadelphia, Pennsylvania, USA |
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| Abstract: | A new class of diarylsulfones, in which tetrahydrobenzazepine comprises one of the aromatic moieties, has been synthesized via the acid‐catalyzed rearrangement of several substituted benzazepinesulfonamides. The rearrangement is normally ortho but in at least one case a para isomer is also formed. Sulfones of this type have been shown to possess potent anti‐HIV activity. |
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| Keywords: | Acid‐catalyzed rearrangements benzazepine sulfonamides sulfones |
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