Improved Experimental Procedure for the Synthesis of the Potent MEK Inhibitor PD184352 |
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| Authors: | Natalia Shpiro |
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| Institution: | Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences , University of Dundee , Dundee, Scotland, UK |
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| Abstract: | An improved synthesis of the potent MEK inhibitor PD184352 (2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide)) is herein reported. This new and reproducible protocol provides a simple and efficient way of generating gram quantities of PD184352 with minimal purification. |
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| Keywords: | Inhibitor Hydroxylamines PD184352 |
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