Synthesis and antitumor activity evaluation of some 1, 2, 4-triazine and fused triazine derivatives |
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Authors: | Mohsen K. Abou-Elregal Amira T. A. Mohamed Ahmed S. A. Youssef Magdy M. Hemdan Wael S. I. Abou-Elmagd |
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Affiliation: | Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt Abassia |
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Abstract: | Reactions of 3-hyrazino-5,6-diphenyl-1,2,4-triazine with various carbonyl compounds such as ethyl acetoacetate, acetylacetone, benzoin, isatin, phthalic anhydride, phenyl isocyanate and acetic anhydride were discussed. Its reactions with α, β unsaturated compounds such as arylidinemalononitrile, diethyl acetylenedicarboxylate, dibenzylidine hydrazine were studied. These reactions led to the formation of various triazine and fused-triazine derivatives. The antitumor activity of the synthesized compounds was tested against HePG2 and MCF-7 cell lines. Some of the tested compounds were most active, whereas other compounds exhibited little or no activity. |
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Keywords: | 1 2 4-Triazine triazolotriazine triazinotriazepine triazinotriazine |
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