Ultrasound-Promoted Environmentally Friendly Synthesis of 5-(3,3,3-Trifluoro-2-oxopropylidene)pyrrolidin-2-ones |
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| Authors: | Márcia S F Franco Gleison A Casagrande Cristiano Raminelli Sidnei Moura Marcelo Rossatto Frank H Quina |
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| Institution: | 1. Grupo de Pesquisa em Síntese e Caracteriza??o Molecular, Faculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Dourados, Brazil;2. Departamento de Ciências Exatas e da Terra, Universidade Federal de S?o Paulo, Diadema, Brazil;3. Universidade de Caxias do Sul, Caxias do Sul, Brazil;4. Instituto Federal Farroupilha, Panambi, Brazil;5. Departamento de Química Fundamental, Instituto de Química, Universidade de S?o Paulo, S?o Paulo, Brazil |
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| Abstract: | A facile, one-pot, ultrasound-promoted synthesis of N-substituted 5-(3,3,3-trifluoro-2-oxopropylidene)pyrrolidin-2-ones from methyl 7,7,7-trifluoro-4-methoxy-6-oxohept-4-enoate and a wide range of primary alkyl(aryl)amines using ethanol as a green solvent and employing triethylamine as a base is described. |
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| Keywords: | 5-Alkylidenepyrrolidin-2-ones γ-alkylidene-γ-lactams" target="_blank">γ-alkylidene-γ-lactams [CCCC + N] cyclocondensations pyrrolidin-2-ones trifluoromethyl ultrasound |
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