Convenient and Scalable Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives and Their Anticancer Activities |
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| Authors: | Lingayya Rajaka Nageshwar Rao Penumati Y Poornachandra C Ganesh Kumar |
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| Institution: | 1. Organic and Biomolecular Chemistry Division, Council of Scientific and Industrial Research–Indian Institute of Chemical Technology, Hyderabad, India;2. Medicinal Chemistry and Pharmacology Division, Council of Scientific and Industrial Research–Indian Institute of Chemical Technology, Hyderabad, India |
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| Abstract: | An efficient and mild InBr3-catalyzed approach to synthesize 2,3-dihydroquinazolin-4(1H)-one derivatives (3a–3aa) has been developed. Notably, all the products were isolated by recrystallization and the reaction is accessible on a gram scale. Moreover, the reactions only require 10–60 min. All the synthesized compounds were evaluated for their in vitro anticancer activity against four human cancer cell lines. |
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| Keywords: | Anticancer activity aromatic aldehydes cyclocondensation 2 3-dihydroquinazolin-4(1H)-ones indium(III) bromide |
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