Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation |
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| Authors: | Shymaa A Abbass Heba A Hassan Gamal El-Din A Abuo-Rahma |
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| Institution: | Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt |
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| Abstract: | AbstractWe developed a facile one-pot procedure for the synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thione under ultrasonic irradiation. The method is based on a three components reaction of aldehydes, ketones, and thiourea under basic conditions affording isolated yields of up to 95% within a reaction time of 30–90?min. |
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| Keywords: | Biginelli reaction 4 6-diaryl-3 4-dihydropyrimidine-2(1H)-thiones multi-component reactions one-pot synthesis ultrasound |
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