Synthesis of Potential Impurities of Bicalutamide |
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| Authors: | Nandu Baban Bhise Dhananjay Govind Sathe Tarur Radhakrishanan Raviraj Deore |
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| Institution: | 1. CPRL, USV Limited , Mumbai, India nandu.bhise@usv.co.in;3. CPRL, USV Limited , Mumbai, India |
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| Abstract: | Bicalutamide is an oral nonsteroidal, anti-androgen drug used for prostate cancer. It binds to the androgen receptor. During the bulk synthesis of bicalutamide, various impurities are formed. The present work details the development of simple processes for the preparation of impurities of bicalutamide, viz bical-sulfoxides (6), bical-deshydroxy (10), bical-desfluoro (10a), bical-2-fluoro (10b), and bical-3-fluoro (10c). |
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| Keywords: | Anti-androgen bicalutamide Casodex impurities non-steroidal |
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