Methylation of Dimedone |
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| Authors: | Robin D Clark John E Ellis Clayton H Heathcock |
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| Institution: | Department of Chemistry , University of California , Berkeley, California, 94720 |
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| Abstract: | In connection with our synthetic approach to pentacyclic triterpenes,1 we have required substantial amounts of 2,5,5-trimethyl-1,3-cyclohexanedione (methyldimedone, 2), which is available by methylation of dimedone (1).2 However, methylation may also afford the 2,2-dimethyl product 3, the methyl ether 4, and the C, O-dimethyl product 5. |
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