Clean and Convenient One-Pot Synthesis of 4-Hydroxycoumarin and 4-Hydroxy-2-quinolinone Derivatives |
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| Authors: | Wen-Tao Gao Wen-Duan Hou Mei-Ru Zheng Li-Jun Tang |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering , Bohai University , Jinzhou, Liaoning, China isfc@bhu.edu.cn;3. College of Chemistry and Chemical Engineering , Bohai University , Jinzhou, Liaoning, China |
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| Abstract: | ![]()
A simple, efficient, and environmentally friendly procedure has been developed for the reaction of Meldrum's acid with phenol, substituted phenols, aniline, or substituted anilines with Eaton's reagent (phosphoric anhydride + methylsulfonic acid) as cyclization reagent. 4-Hydroxycoumarins and 4-hydroxy-2-quinolinones were synthesized in moderate yields by carrying out the reaction in solvent-free, convenient, and clean one-pot preparation. |
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| Keywords: | Eaton's reagent 4-hydroxycoumarin 4-hydroxy-2-quinolinone one-pot |
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