Convenient Method for the Preparation of Carboxylic Esters Using (Chloromethylene)dimethylammonium Chloride |
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| Authors: | Hitoshi Nagao Makoto Michida |
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| Affiliation: | Center for Basic Research, Kitasato Institute , Tokyo, Japan |
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| Abstract: | ![]()
(Chloromethylene)dimethylammonium chloride (Vilsmeier reagent) works as an efficient condensation reagent in the formation of carboxylic esters from carboxylic acids and alcohols under mild conditions in a one-pot procedure. Secondary alcohols are converted successively into the corresponding esters in moderate to high yields with inversion of configurations. |
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| Keywords: | Condensation inversion mild conditions one-pot Vilsmeier reagent |
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