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Efficient Synthesis of Aryl Methyl Sulfide Derivatives Using (Methylthio)trimethylsilane as Methylthiolation Reagent |
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| Authors: | Qi Qiao Achyutharao Sidduri Jianping Lou Robert A. Goodnow Jr. |
| Affiliation: | Roche Research Center, Hoffmann-La Roche Inc. , Nutley, New Jersey, USA |
| Abstract: | The synthesis of various aryl methyl sulfides has been achieved by treatment of nitroarenes with a combination of (methylthio)trimethylsilane and cesium carbonate in dimethylsulfoxide. This reaction gives access to aryl methyl sulfide derivatives in high yields. |
| Keywords: | Aryl methyl sulfides methylthiolation (methylthio)trimethylsilane nitroarenes nucleophilic displacement |