Copper-Catalyzed Cyanopropylation of Activated Alkenes |
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| Authors: | Shi Tang Zhi-Hao Li Dong Zhou You-Lin Deng Guo-Liang Ding Qian Zhang |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Central South University, Changsha, China;2. College of Chemistry and Chemical Engineering, Jishou University, Jishou, Chinashitang@126.com;4. College of Chemistry and Chemical Engineering, Jishou University, Jishou, China |
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| Abstract: | ![]()
A practical copper-catalyzed alkylarylation of activated alkenes with azobisisobutyronitrile (AIBN) and beyond has been developed, in which incorporation of 3o nitrile moiety into an oxindole scaffold proceeded smoothly through cascade radical addition/C(sp2)-H cyclization. The use of readily available AIBN as radical source and inexpensive CuI as catalyst, as well as broad substrate scope and the simplicity of operation and handling, make this protocol a highly attractive approach to oxindoles bearing 3o nitrile moiety. |
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| Keywords: | 3° nitrile AIBN Cu catalysis cyanopropylation oxindole |
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