Synthesis of Optically Active 1,4-Dioxane Nucleotide Analogs |
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| Authors: | Qiang Yu Stefanie Kaffarnik |
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| Affiliation: | 1. Department of Chemistry , Norwegian University of Science and Technology , Trondheim, Norway;2. Department of Chemistry , University of Hamburg , Hamburg, Germany |
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| Abstract: | Optically active nucleotide analogs were prepared that were composed of a 1,4-dioxane ring as the sugar analog to which either uracil or adenine attached together with two carboxylic ester groups, to be used as vehicles for formation of oligomers. The chiral 1,4-dioxane moiety was constructed from dimethyl L-tartrate via the corresponding (2R,3R)-dimethyl 2-O-allyl-tartrate. |
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| Keywords: | Chiral pool chiral synthesis cyclization nucleotide analogs oxygen heterocycles |
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