Synthesis of 3-Trifluoromethyl-Substituted Benzo[f]chromene Derivatives in a One-Pot Reaction |
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| Authors: | Hua-Fang Fan Xiao-Wei Wang Jing-Wei Zhao Xin-Jin Li Jin-Ming Gao |
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| Affiliation: | 1. Shaanxi Engineering Center of Bioresource Chemistry and Sustainable Utilization, College of Science, Northwest A &2. F University , Yangling , Shaanxi , China;3. Key Laboratory of Organofluorine Chemistry , Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai , China |
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| Abstract: | In the presence of 1,8-diazabicycolo[5.4.0]undec-7-ene (DBU) and concentrated H2SO4, 2-naphthol reacted smoothly with α,β-unsaturated trifluoromethyl ketones in CH2Cl2 at room temperature, affording the 3-trifluoromethyl-substituted benzo[f]chromene derivatives in good to excellent yields in a one-pot reaction. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource: Full experimental and spectral details]. |
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| Keywords: | Benzo[f]chromene 2-naphthol one-pot reaction roman" >α, roman" >β-unsaturated trifluoromethyl ketone |
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