Efficient Synthesis of Symmetrical Bisamides from Aldehydes and Amides Catalyzed by Silica-Bonded S-Sulfonic Acid Nanoparticles |
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Authors: | Mahmood Tajbakhsh Rahman Hosseinzadeh Heshmatollah Alinezhad Parizad Rezaee |
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Institution: | 1. Department of Organic Chemistry, Faculty of Chemistry , University of Mazandaran , Babolsar , Iran tajbaksh@umz.ac.ir;3. Department of Organic Chemistry, Faculty of Chemistry , University of Mazandaran , Babolsar , Iran |
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Abstract: | Silica-bonded S-sulfonic acid nanoparticles (SBSSANPs) were easily synthesized from silica nanoparticles and showed to be an efficient catalyst in the synthesis the symmetrical N,N′-alkylidene bisamides. Reaction of aldehydes and amides in the presence of the catalyst afforded the corresponding bisamides in good to excellent yields. The extensive range of substrates suggests general applicability of the method. Reusability of the catalyst, simple workup procedure, and short reaction times are other advantages of this protocol. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications ® to view the free supplemental file. |
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Keywords: | Aldehydes amides bisamides silica-bonded S-sulfonic acid nanoparticles supported catalyst |
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