Convenient Synthesis of 2-Allyl-3-bromo-1,4-dimethoxynaphthalene: Key Intermediate as Building Block for Bioactive Pyranonaphthoquinones |
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| Authors: | Rohan A Limaye Pinki Gaur Madhusudan V Paradkar |
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| Institution: | Department of Chemistry , Postgraduate and Research Centre, MES Abasaheb Garware College , Pune , India |
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| Abstract: | Synthesis of a key precursor 2-allyl-3-bromo-1,4-dimethoxynaphthalene (1) used in constructing various naturally occurring biologically active pyranonaphthoquinones is carried out utilizing easily available 1-methoxynaphthalene as a starting material. The synthesis was accomplished with Dakin's oxidation and Claisen rearrangement, thereby providing another easy approach toward (1) without involving highly lachrymatric 2-bromonaphthoquinone. |
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| Keywords: | 2-Allyl-3-bromo-1 4-dimethoxynaphthalene Claisen rearrangement Dakin's oxidation pyranonaphthoquinones |
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