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Synthesis of Benzopyran-4-Amides Potassium Channel Openers Via Palladium-Catalyzed Amidation |
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| Authors: | Naoki Taka Hiroshi Koga Haruhiko Sato Takenori Ishizawa Tadakatsu Takahashi |
| Affiliation: | Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Company, Ltd. , 135, 1--Chome Komakado, Gotemba-shi, Shizuoka, 412--8513, Japan |
| Abstract: | The novel potassium channel openers benzopyran-4-amides have been synthesized via palladium-catalyzed amidation of 4-bromobenzopyrans under an atmoshere in the presence of an equivalent of potassium iodide. |
| Keywords: | |