A New Efficient Synthesis of 4-Alkoxy-1,6-diaryl-1H-pyrazolo[3,4-d]pyrimidine Derivatives |
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| Authors: | Ju Liu Xin-wei Zhang Yang Wang Ye Chen Mei-rong Zhang Zhi-qiang Cai |
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| Affiliation: | 1. College of Pharmacy, Liaoning University, Shenyang, Chinaliuju1216@126.com;3. College of Pharmacy, Liaoning University, Shenyang, China;4. School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang, China |
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| Abstract: | ![]()
A new synthesis of 4-methoxy (or ethoxy)-1,6-diaryl-1H-pyrazolo[3,4-d]pyrimidine derivatives is described. An efficient one-step methodology for the title compounds was achieved by using 5-amino-1-aryl-1H-pyrazole-4-carbonitriles with arylaldehydes in CH3OH or C2H5OH and NaOH at 60 °C. The new compounds were obtained in moderate to good yields as stable solids and easily purified by filtration. |
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| Keywords: | Arylaldehyde cyclization reaction ortho-aminonitrile pyrazolo[3,4-d]pyrimidine |
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