Traceless Sulfone Linker for the Solid-Phase Organic Synthesis of 1-(E)-Styryl-4-substituted-1,2,3-triazoles |
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| Authors: | Jian-Wen Jiang Shou-Ri Sheng Xiao-Lan Zhang Zheng Fang Ming-Zhong Cai |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang , China;2. Department of Chemistry , Shangrao Normal College , Shangrao , China |
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| Abstract: | A novel, facile, solid-phase, organic synthesis of 1-(E)-styryl-4-substituted-1,2,3-triazoles in good yields and purities via traceless sulfone linker has been developed. Key steps involved in this synthetic procedure include (i) sulfone alkylation of sulfinate resin with (2-azido-1-iodoethyl)benzene, (ii) 3 + 2] cycloaddition with terminal alkynes in the presence of CuI, and (iii) traceless product release by base-mediated elimination process. |
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| Keywords: | Click chemistry 1 4-disubstituted-1 2 3-triazole elimination reaction 1-(E)-styryl substituent solid-phase organic synthesis sulfone linker |
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