A metal-free approach to access ketones,amides, and nitriles employing TBAI/TBHP oxidative system in water |
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| Authors: | Suzane Quintana Gomes |
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| Institution: | Department of Organic Chemistry, Institute of Chemistry, University of Campinas, Campinas, S?o Paulo, Brazil |
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| Abstract: | Hydrocarbons, benzylamines, and heteroaromatic-bearing amines have been efficiently employed as substrates in allylic and benzylic oxidations via C(sp3)–H bond activation by TBAI/TBHP in water. This operationally simple method allows access to ketones, nitriles, and amides in moderate to high yields and a regio- and chemoselective late-stage functionalization. |
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| Keywords: | Allylic oxidation benzylic oxidation in water metal-free oxidation |
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