Improved Synthesis of N,N′‐Disuccinimidyl Carbonate using α‐Pinene as Acid Scavenger |
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Authors: | Maddipati Prasad Shaik Nowshuddin |
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Institution: | Divis Laboratories Limited , Hyderabad , India |
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Abstract: | An improved synthesis of N,N′‐disuccinimidyl carbonate (DSC) is described where α‐pinene is utilized as an efficient scavenger of HCl liberated during the reaction of N‐hydroxysuccinimide with triphosgene in THF. The α‐pinene hydrochloride formed is soluble in THF and gives very pure DSC in good yields. |
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Keywords: | Acid scavenger N N′‐disuccinimidyl carbonate α‐pinene |
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