One-Pot Synthesis of 1H-Benzimidazole Derivatives Using Thiamine Hydrochloride as a Reusable Organocatalyst |
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| Authors: | Min Lei |
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| Affiliation: | Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica , Shanghai , China |
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| Abstract: | ![]()
A simple and efficient one-pot synthesis of 1H-benzimidazole derivatives using thiamine hydrochloride (VB1) as the organocatalyst from o-phenylenediamine and aldehyde in dimethylformamide is described. Compared to classical reaction conditions, this new method consistently has the advantages of excellent yields, metal-ion-free procedure, and good recovery and reusablity of catalyst. |
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| Keywords: | Aldehyde 1H-benzimidazole green chemistry o-phenylenediamine thiamine hydrochloride (VB1) |
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