Synthesis,ABTS-Radical Scavenging Activity,and Antiproliferative and Molecular Docking Studies of Novel Pyrrolo[1,2-a]quinoline Derivatives |
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| Authors: | Chandrika Nanjappa Gopalpur Nagendrappa Pasura Subbaiah Sujan Ganapathy Shirur Dakappa Shruthi Sunil S More |
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| Institution: | 1. Postgraduate Department of Chemistry, Jain University, Bengaluru, Karnataka, India;2. Research and Development Centre, Olive Lifesciences Pvt. Ltd., Bengaluru, Karnataka, India;3. Microbiology and Cell Biology Department, Indian Institute of Science, Bengaluru, Karnataka, India;4. Postgraduate Department of Biochemistry, Center for Post Graduate Studies, Jain University, Bengaluru, India |
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| Abstract: | A new 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-radical scavenging and antiproliferative agents of pyrrolo1,2-a]quinoline derivatives have been synthesized. An efficient method for the synthesis of 14 novel diversified pyrrolo1,2-a]quinoline derivatives has been described using 4-(1,3-dioxolan-2-yl)quinoline and different phenacyl bromides in acetone and followed by reacting with different acetylenes in dimethylformamide/K2CO3. The structure of the newly synthesized compounds was determined by infrared, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The in vitro antioxidant activity revealed that among all the tested compounds 5n exhibited maximum scavenging activity with ABTS. Compound 5b has showed good antiproliferative activity as an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. |
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| Keywords: | ABTS-radical scavenging activity antiproliferative activity 1 3-dipolar cycloaddition molecular docking pyrrolo[1 2-a]quinoline quinoline 4-carbaldehyde |
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