Synthesis of Cholesterylated Thiogalactosides for Gene Delivery |
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| Authors: | Li Hai Jiang Fan Zhirong Zhang Guoyao Zhang Yong Wu |
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| Institution: | Key Laboratory of Drug Target, West China School of Pharmacy , Sichuan University , Chengdu, Sichuan, China |
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| Abstract: | A series of cholesterylated thiogalactosides L1 –L6 the cell targeting ligands for gene delivery to hepatocytes, was synthesized. Related poly(ethylene glycol) chain was used as a bridge for the attachment of galactoside on one hydroxyl end, while the other hydroxyl end was linked with cholesterol. This design provided an effective entry for the synthesis of a poly(ethylene glycol) compound with the hepatocyte targeting. |
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| Keywords: | Cholesterylated thiogalactoside gene delivery poly(ethylene glycols) (PEG) targeting ligand |
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