Straightforward Method for the Preparation of Lysine-Based Double-Chained Anionic Surfactants |
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| Authors: | Paula Gomes Maria João Araújo Eduardo F. Marques Soraia Falcão Rodrigo O. Brito |
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| Affiliation: | 1. CIQUP, Department of Chemistry, Faculty of Sciences , University of Porto , Porto, Portugal pgomes@fc.up.pt;3. CIQUP, Department of Chemistry, Faculty of Sciences , University of Porto , Porto, Portugal |
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| Abstract: | Double-chained surfactants with potential biocompatibility have been prepared in high yields by lysine acylation with four natural saturated fatty acids (C6 to C12) and with cis-undec-5-enoic acid. The surfactants were found to assemble into nanotubules in aqueous medium and, when mixed with a commercial cationic surfactant, to spontaneously form liposomes. |
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| Keywords: | Carbodiimide Coupling Fatty acid Liposome Lysine Peptide Surfactant |
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