KF/Al2O3: Solid-Supported Reagent Used in 1,3-Dipolar Cycloaddition Reaction of Nitrile Oxide |
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| Authors: | Monalisa Boruah Dilip Konwar |
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| Affiliation: | 1. Department of Chemistry , Indian Institute of Technology , New Delhi , India lisadergaon@yahoo.co.in;3. Synthetic Organic Chemistry Division , North East Institute of Science and Technology , Jorhat , India |
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| Abstract: | ![]()
The stereoselective synthesis of 2-isoxazolidine through 1,3-dipolar cycloaddition reaction of nitrile oxide, which is in situ generation from aldoxime in the presence of N-bromosuccinamide and solid-supported reagent KF/Al2O3 at room temperature, is reported. KF/Al2O3 is sufficiently basic such that it can replace organic bases such as Et3N used in typical procedures and it catalyses the reaction to enhance the rate of the reaction. |
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| Keywords: | 1,3-Dipolar cycloaddition reaction KF/Al2O3 NBS nitrile oxide solid-supported reagent |
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