Facile Synthesis of Spiro Oxindoles,Azaoxindoles, and Dihydroisoquinolone |
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| Authors: | Sharada S. Labadie Christa Parmer |
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| Affiliation: | 1. Department of Medicinal Chemistry , Roche Palo Alto LLC , Palo Alto , California , USA labadie.sharada@gene.com;3. Department of Medicinal Chemistry , Roche Palo Alto LLC , Palo Alto , California , USA |
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| Abstract: | Formation of 1-aryl-4-oxo-cyclohexa(e)nonecarboxylates from the Diels–Alder cycloaddition of 2-trimethylsilyloxy-1,3-butadiene and Danishefsky diene with aryl- and pyridylacrylates and further conversion thereof to spirocycles is described. This provides an efficient method for spiro oxindoles, azaoxindoles, and dihydroisoquinolones.  Additional information ACKNOWLEDGMENTS The authors acknowledge Dr. Francisco Talamas and Dr. Josh Taygerly for their valuable input and the analytical department for providing the spectroscopic and physical data. |
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| Keywords: | Azaoxindoles Diels–Alder reaction dihydroisoquinolone spirocycles |
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