Synthesis,Structural Stability Calculation,and Antibacterial Evaluation of Novel 3,5-Diphenylcyclohex-2-en-1-one Derivatives |
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Authors: | Omyma A Abd Allah Asmaa M Kadry |
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Institution: | Chemistry Department, Faculty of Science, Sohag University, Sohag, Egypt |
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Abstract: | Starting with 3,5-diphenylcyclohex-2-en-1-one, 3,5-diphenylcyclohex-2-en-1-semicarbazone, 1-chloro-3,5-diphenylcyclohex-2-en-2-carbaldehyde, and 3,5-diphenylcyclohex-2-en-1-hydrazone were synthesized via the reactions with semicarbazide hydrochloride, POCl3/ dimethylformamide, and hydrazine hydrate, respectively. These products were used as key intermediates for the preparation of novel series of tetrahydrobenzothiadiazol-1-oxide, indazole, benzo-thiazepines, pentahydroxyhexylidene and N-thiazines. Some of these derivatives exhibit high antibacterial activity against Gram-positive bacteria. |
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Keywords: | Antibacterial diphenylcyclohexenone indazole pentahydroxyhexylidene tetrahydrobenzothiazepine thiazolidinone |
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