One-pot practical method for synthesis of functionalized 4H-chromen-5-one derivatives under catalyst and solvent-free conditions |
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Authors: | M Musawwer Khan Biswas Saigal Sumbulunnisan Shareef Sarfaraz Khan Subash C Sahoo |
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Institution: | 1. Department of Chemistry, Aligarh Muslim University, Aligarh, India;2. musawwer@gmail.com;4. Department of Chemistry and Center of Advanced Studies in Chemistry, Panjab University, Chandigarh, India |
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Abstract: | AbstractA facile and practical method was described for the synthesis of 4H-chromen-5-ones under catalyst- and solvent-free conditions by one-pot stirring of starting materials at 110?°C. The products were obtained by the reaction between cyclic 1,3-dicarbonyl compounds, aromatic aldehydes and (E)-N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) in short duration with good to excellent yields. This simple and environmentally benign method eliminates the use of expensive, metallic and corrosive catalysts, hazardous organic solvents, and chromatographic separation. |
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Keywords: | Catalyst-free multicomponent reaction solvent-free 4H-Chromen-5-ones (E)-N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) |
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