Zinc-Mediated Facile and Efficient Chemoselective S-Alkylation of 5-Aryl-1,3,4-oxadiazole-2-thiols in the Absence of Base |
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| Authors: | M. S. R. Murty Rayudu Venkateswara Rao Kesur R. Ram N. Rami Reddy J. S. Yadav B. Sridhar |
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| Affiliation: | 1. Organic Chemistry Division I, Indian Institute of Chemical Technology , Hyderabad, India msrmurty@ymail.com;3. Organic Chemistry Division I, Indian Institute of Chemical Technology , Hyderabad, India;4. Laboratory of X-ray Crystallography, Indian Institute of Chemical Technology , Hyderabad, India |
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| Abstract: | ![]()
Zinc-mediated facile and efficient chemoselective S-alkylation of 5-aryl 1,3,4-oxadiazole-2-thiols in the presence of a catalytic amount of tetra butyl ammonium iodide was described. The reaction was performed under neutral conditions. The chemoselectivity of the alkylation was confirmed by NMR spectroscopy and x-ray crystallography. |
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| Keywords: | Alkylation chemoselectivity oxadiazole piperazines zinc |
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