ZnO Nanoparticles as an Efficient,Heterogeneous, Reusable,and Ecofriendly Catalyst for One-Pot,Three-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-(thio)one Derivatives in Water |
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| Authors: | Akbar Hassanpour Rahim Hosseinzadeh Khanmiri Jafar Abolhasani |
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| Affiliation: | 1. Department of Chemistry, Marand Branch, Islamic Azad University, Marand, Iranhassanpour@marandiau.ac.ir;3. Department of Chemistry, Shahid Beheshti University, Tehran, Iran;4. Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran |
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| Abstract: | ![]()
An extremely efficient heterogeneous protocol is reported for the one-pot, three-component synthesis of a series of dihydropyrimidinones (DHPMs) in the presence of ZnO nanoparticles in water as a green solvent. The ZnO nanoparticles exhibited excellent catalytic activity and the proposed methodology is capable of providing the desired products in good yields (65–94%) within short reaction times. After the reaction course, ZnO nanoparticles can be recycled and reused without any apparent loss of activity, which makes this ecofriendly process cost-effective. |
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| Keywords: | Biginelli reaction dihydropyrimidinone green chemistry multicomponent reaction ZnO nanoparticles |
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