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Polymer-Supported Vinyl Sulfone as an Efficient Reagent for the Synthesis of 3-Monosubstituted Isoxazoles |
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| Authors: | Guo-Jian Wu Dan Li Li-Fan Xu Zhen-Zhong Huang |
| Affiliation: | College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang , P.R. , China |
| Abstract: | Polystyrene-supported vinyl sulfone reagent has been developed and used for solid-phase organic synthesis of 3-monosubstituted isoxazoles by 1,3-dipolar cycloaddition reaction with nitrile oxides and subsequent cleavage from the polymer support through an elimination reaction in the presence of potassium tert-butoxide. The advantages of this method include straightforward operation, good yield, and high purity of the crude products. |
| Keywords: | 1,3-Dipolar cycloaddition elimination reaction 3-monosubstituted isoxazole polystyrene-supported vinyl sulfone solid-phase organic synthesis |