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Amine Salt–Catalyzed Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles |
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| Authors: | Yi Zhou Renjie Ni Gaowen Yang |
| Institution: | 1. Department of Applied Chemistry , College of Science, Nanjing University of Technology , Nanjing, China;2. Jiangsu Laboratory of Advanced Functional Materials, Changshu Institute of Technology , Changshu, China;3. Department of Applied Chemistry , College of Science, Nanjing University of Technology , Nanjing, China;4. Jiangsu Laboratory of Advanced Functional Materials, Changshu Institute of Technology , Changshu, China |
| Abstract: | The 3 + 2] cycloaddition reaction between sodium azide and various organic nitriles proceeds smoothly in the presence of amine salts as catalyst in dimethylformamide. The corresponding 5-substituted 1-H tetrazoles were obtained under mild condition in good to excellent yields. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
| Keywords: | Amine salt catalyst azide [3 + 2] cycloaddition heterocycles tetrazole |