Etude Stéréochimique par RMN 1H de Tetrahydropyrannes β-Chlorés α-Substitués |
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Authors: | Jacques Delaunay Alain Lebouc Olivier Riob |
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Institution: | Jacques Delaunay,Alain Lebouc,Olivier Riobé |
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Abstract: | The 1H NMR study of 2-alkyl-3-chlorotetrahydropyrans, obtained by reaction of Grignard reagents with a mixture of cis/trans-2,3-dichlorotetrahydropyrans, shows cis/trans configuration of two isomers in which the alkyl substituents are exclusively in the equatorial position. 3-Chloro-2-phenyltetrahydropyran exists in trans (eq-eq) configuration only. The 1H NMR study of cis/trans 2-alkoxy (or aryloxy)-3-chlorotetrahydropyrans, obtained by reaction of alcohols or phenol with 2,3-dichlorotetrahydropyrans, shows the axial position of the alkoxy (or aryloxy) substituent. |
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