Neuronal expression of muskelin in the rodent central nervous system |
| |
| Authors: | Nadia Tagnaouti Sven Loebrich Frank Heisler Yvonne Pechmann Susanne Fehr Adèle De Arcangelis Elisabeth Georges-Labouesse Josephine C Adams Matthias Kneussel |
| |
| Affiliation: | (1) Zentrum fr Molekulare Neurobiologie Hamburg, ZMNH, Universitt Hamburg, Germany;(2) Institut de Gntique et de Biologie Molculaire et Cellulaire, IGBMC, CNRS/INSERM/ULP, Parc d'Innovation, Illkirch, Strasbourg, France;(3) Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA |
| |
| Abstract: | Background The kelch repeat protein muskelin mediates cytoskeletal responses to the extracellular matrix protein thrombospondin 1, (TSP1), that is known to promote synaptogenesis in the central nervous system (CNS). Muskelin displays intracellular localization and affects cytoskeletal organization in adherent cells. Muskelin is expressed in adult brain and has been reported to bind the Cdk5 activator p39, which also facilitates the formation of functional synapses. Since little is known about muskelin in neuronal tissues, we here analysed the tissue distribution of muskelin in rodent brain and analysed its subcellular localization using cultured neurons from multiple life stages. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
