Regulation of nestin expression by thrombin and cell density in cultures of bone mesenchymal stem cells and radial glial cells |
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Authors: | Franz Wautier Sabine Wislet-Gendebien Grazyna Chanas Bernard Rogister Pierre Leprince |
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Institution: | (1) Center for Cellular and Molecular Neurobiology, University of Lige, Avenue de l'Hpital, 1, B-4000, CHU B36 Lige, Belgium;(2) Department of Neurology, University of Lige, B-4000, CHU B35 Lige, Belgium;(3) Department of Biochemistry and Cell Physiology, University of Lige, B-4000, CHU B35 Lige, Belgium |
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Abstract: | Background Bone marrow stromal cells and radial glia are two stem cell types with neural phenotypic plasticity. Bone marrow mesenchymal
stem cells can differentiate into osteocytes, chondrocytes and adipocytes, but can also differentiate into non-mesenchymal
cell, i.e. neural cells in appropriate in vivo and in vitro experimental conditions. Likewise, radial glial cells are the progenitors of many neurons in the developing cortex, but can
also generate astrocytes. Both cell types express nestin, an intermediate filament protein which is the hallmark of neural
precursors. |
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Keywords: | |
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