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| 3-(3,4,5-三甲氧基苯基)-4-氨基-5-取代苄巯基-1,2,4-三唑的合成及其生物活性 | |
| 引用本文： | 杜海军,杜海堂,桑维钧,王慧.3-(3,4,5-三甲氧基苯基)-4-氨基-5-取代苄巯基-1,2,4-三唑的合成及其生物活性[J].合成化学,2012,20(1):76-79. |
| 作者姓名： | 杜海军 杜海堂 桑维钧 王慧 |
| 作者单位： | 1. 贵州民族学院化学与环境科学学院,贵州贵阳,550025 2. 贵阳学院化学系,贵州贵阳,550005 3. 贵州大学农学院,贵州贵阳,550025 |
| 基金项目： | 贵州省科学技术基金，贵州省教育厅自然科学基金，贵阳市人才创新创业资助项目 |
| 摘 要： | 3-(3,4,5-三甲氧基苯基)-4-氨基-5-巯基-1,2,4-三唑与取代苄氯反应合成了九个新型3-(3,4,5-三甲氧基苯基)-4-氨基-5-取代苄巯基-1,2,4-三唑(2a～2i),其结构经1H NMR,IR和MS表征.初步生物活性测试结果表明,3-(3,4,5-三甲氧基苯基)-4-氨基-5-对氯苄巯基-1,2,4-三唑(2b)对半夏立枯病菌具有抑制活性. |
| 关 键 词： | 4-氨基三唑 三唑硫醚 合成 杀菌活性 |
Synthesis of 3- (3,4,5-Trimethoxyphenyl) -4-amino-5- ( substituted thiobenzyl ) -1,2,4-triazoloes and Their Biological Activity |
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| DU Hai-jun , DU Hai-tang , SANG Wei-jun , WANG Hui.Synthesis of 3- (3,4,5-Trimethoxyphenyl) -4-amino-5- ( substituted thiobenzyl ) -1,2,4-triazoloes and Their Biological Activity[J].Chinese Journal of Synthetic Chemistry,2012,20(1):76-79. | |
| Authors: | DU Hai-jun DU Hai-tang SANG Wei-jun WANG Hui |
| Institution: | 1.School of Chemistry and Environment Science,Guizhou University for Nationalites,Guiyang 550025,China; 2.Department of Chemistry,Guiyang College,Guiyang 550005,China; 3.Agricultural College,Guizhou University,Guiyang 550025,China) |
| Abstract: | Nine novel 3-(3,4,5-trimethoxyphenyl)-4-amino-5-(substituted thiobenzyl)-1,2,4-triazoloes(2a~2i) were synthesized by the reaction of 3-(3,4,5-trimethoxybenzyl)-4-amino-5-mercapto-1,2,4-triazole with substituted benzyl chloride.The structures were characterized by 1H NMR,IR and MS.Preliminary bioassays indicated that 3-(3,4,5-trimethoxyphenyl)-4-amino-5-(4-chlorothiobenzyl)-1,2,4-triazoloe(2b) exhibited fungicidal activity against R.solani. |
| Keywords: | 4-amino triazoles triazolo thioethers synthesis fungicidal activity |
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