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A facile synthesis of novel 1,4-benzoxazepin-2-one derivatives |
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| Authors: | Fatemeh KhaleghiLaily Bin Din Ibrahim JantanWan Ahmad Yaacob Mohammad A Khalilzadeh |
| Institution: | a School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia b Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia c Department of Basic Science, Science and Research Branch, Islamic Azad University, Mazandaran, Iran |
| Abstract: | An efficient and simple synthesis of 1,4-benzoxazepin-2-one derivatives has been achieved via the reaction of isoquinoline, activated acetylenes, and 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone in water without using any catalyst. This one-pot reaction occurs in high yields under mild conditions. |
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