On the Reach of Chemical Synthesis: Creation of a Mini‐Pipeline from an Academic Laboratory |
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| Authors: | Rebecca M. Wilson Samuel J. Danishefsky Prof. |
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| Affiliation: | 1. Laboratory for Bioorganic Chemistry, Sloan‐Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065 (USA);2. Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027 (USA) |
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| Abstract: | In this retrospective, we recall some select cases of synergy between very challenging chemical synthesis and the identification of promising new candidates for pharmaceutics development. The progression from targets, often referred to as small molecules, to those of a size commonly associated with biologics (including glycoproteins) is also charted. |
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| Keywords: | carbohydrates drug discovery natural products total synthesis vaccines |
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