Spectroelectrochemical Study of 9‐Substituted Acridines with Potential Antitumor Activity |
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| Authors: | Iuliu O Marian Nicolae Bonciocat Cecilia Cristea Robert Săndulescu Monica Bucşa Mircea Vlassa |
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| Institution: | 1. Physical Chemistry Department, Faculty of Chemistry and Chemical Engineering, “Babe?‐Bolyai” University, 11 Arany Janos St, 400021?Cluj‐Napoca, Romania;2. Analytical Chemistry Department, Faculty of Pharmacy, “Iuliu Ha?ieganu” University of Medicine and Pharmacy, 4 Pasteur St., 400 349 Cluj‐Napoca, Romania |
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| Abstract: | The electrochemical and spectroelectrochemical behavior of 9‐substituted with ? CN and ? COOH acridine N‐oxides with potential antitumor activity was investigated. In SER spectra of the investigated compounds, the ring stretching vibration at 1568 cm?1 for 9‐CN‐substituted compound respectively 1639 cm?1 for 9‐COOH‐substituted compound was analyzed. Cyclic voltammograms indicates that the reduction potential ?0.766 V for ? CN substituted compound increase towards ?0.745 V for ? COOH substituted compound. The proposed theoretical method in the electrochemical impedance spectroscopy uses a reference redox dielectrode and a multielectrode containing the compound. To account for the change of electrochemical impedance we have considered two theoretical quantities: a pseudocapacitance and a pseudo inductance. Two possible arrangements of them: in series, respective in parallel can be used like criteria of drug classification. |
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| Keywords: | Acridines derivatives Antitumor agents Nyquist plots Raman spectroscopy |
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