Synthesis,Characterization and Antibacterial Activity of <Emphasis Type="Italic">N</Emphasis>-(<Emphasis Type="Italic">N</Emphasis>-Acetic Acid-yl-Phthalimide-5-yl) Maleamic Acid Dihydrate |
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Authors: | Jian Li |
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Institution: | (1) Department of Chemistry and Chemical Engineering, Weifang University, 261061 Weifang, China |
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Abstract: | Abstract The compound N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid (C14H10N2O7, M
r
= 318) was synthesized and its structure was characterized by elemental analysis, 1H NMR and IR spectra. The single crystal of the title compound (C14H14N2O9, M
r
= 354.27) was cultured and its structure was determined by single crystal X-ray diffraction. The crystal belongs to monoclinic
system, space group P21/c with a = 14.3859(19), b = 12.5835(18), c = 8.6934(15) ?, β = 102.824(2)°, V = 1534.5(4) ?3, Z = 4, D
c
= 1.534 g cm−3, μ(Mo Kα) = 0.131 mm−1, F(000) = 736. The final refinement gave R = 0.0652, wR(F
2) = 0.1239 for 2,703 observed reflections with I > 2σ(I). X-ray diffraction analysis reveals that the asymmetric unit of the title compound contains one N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid molecule and two water molecules. One of the two water molecules is disordered.
The phthalimide group is essentially planar. The crystal structure of the title compound is stabilized by N–H…O and O–H…O
hydrogen bonds interactions. The compound N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid possesses moderate antibacterial activity. |
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Keywords: | |
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