Use of liquid chromatography for separation and determination of carrier species associated with the synthesis of no carrier-added11C-labelled compounds determination of the specific activity of {11C} urea期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Use of liquid chromatography for separation and determination of carrier species associated with the synthesis of no carrier-added11C-labelled compounds determination of the specific activity of {11C} urea

Authors:	Ali M Emran Th E Boothe R D Finn M M Vora P J Kothari

Institution:	(1) Cyclotron Facility, Baumritter Institute of Nuclear Medicine, Mount Sinai Medical Center, 33140 Miami Beach, FL, USA

Abstract:	An analytical technique using reversed-phase liquid chromatography has been developed for the determination of urea at quantities as low as 1 ng to quantitate the amount of non-labelled urea produced during the synthesis of no-carrier-added {¹¹C}urea starting from¹¹CN^–. As a result, the specific activity of the {¹¹C} urea thus prepared was calculated to be as high as 3.5±0.8 Ci/mol.Research supported in part by PHS Grant NINCDS 1 PO1 NS 15639.

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