Synthesis, structure, and antimetastatic activity of thetrans-[Pt(NC5H4C(O)NHC2H4ONO2)2Cl2] complex |
| |
| Authors: | I L Eremenko M A Golubnichaya S E Nefedov A A Sidorov D A Nesterenko N P Konovalova L M Volkova L T Eremenko |
| |
| Institution: | (1) N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 117907 Moscow, Russian Federation;(2) Institute of Chemical Physics in Chernogolovka, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation |
| |
| Abstract: | Thetrans-Pt(NC5H4C(O)NHC2H4ONO2)2Cl2] complex (2) was prepared by the reaction of nicorandyl (N-nitroethoxynicotinamide), which is widely used in cardiology, with K2PtCl4 in water. The structure of2 was established by X-ray structural analysis. It was found that complex2 exhibits high antitumor activity, in particular, antimetastatic activity, unlike the analogous CuII complex with bromine atoms.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1672–1675, September, 1997. |
| |
| Keywords: | platinum complex with nicorandyl antitumor activity |
| 本文献已被 SpringerLink 等数据库收录！ |
|
