Azaindoles. V. Pyrido(4,3-b]indoles (γ-carbolines) fonctionnalisés sur leur sommet 4: Synthèse en une seule étape |
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Authors: | Claire Ducrocq Alain Civier Jeannine Andr-Louisfert Emile Bisagni |
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Institution: | Claire Ducrocq,Alain Civier,Jeannine André-Louisfert,Emile Bisagni |
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Abstract: | In boiling diphenylether phenylhydrazine reacts with 1,2-dihydro-2-oxo-4-hydroxypyridines to give 3,4-dihydro-4-oxo(9H)-pyrido4,3-b]indoles (γ-carbolines) in one step. Nucleophilic displacement of their 4-chloro derivatives by secondary amines affords both 3,4-disubstituted γ-carbolines and chlorination of 2,3-dimethyl-4-oxo(9H)pyrido4,3-b]indoles, as well as methylation of 2-methyl-4-chloro-(9H)pyrido4,3-b]indole leads to derivatives in the (3H)4-substituted pyrido4,3-b] indole series. |
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