| 3-氧杂-8-氮杂双环[3.2.1]辛烷盐酸盐的合成 |
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| 引用本文： | 王荣宽,卓广澜. 3-氧杂-8-氮杂双环[3.2.1]辛烷盐酸盐的合成[J]. 合成化学, 2016, 0(11): 998-1001. DOI: 10.15952/j.cnki.cjsc.1005-1511.2016.11.16056 |
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| 作者姓名： | 王荣宽 卓广澜 |
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| 作者单位： | 浙江理工大学 理学院,浙江 杭州,310018 |
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| 摘 要： | 以己二酸为初始原料,依次经酰氯化,溴代,苄胺环合,水解,还原,脱水环合,氢解脱苄和成盐等8步反应,合成了3-氧杂-8-氮杂双环[3.2.1]辛烷盐酸盐,总收率23%,纯度100%,其结构经1H NMR确证。
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| 关 键 词： | 己二酸 3-氧杂-8-氮杂双环[3.2.1]辛烷盐酸盐 药物合成 |
Synthesis of 3-Oxa-8-azabicyclo[3. 2. 1] octane Hydrochloride |
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| Abstract: | 3-Oxa-8-azabicyclo[3. 2. 1] octane hydrochloride with overall yield of 23% and purity of 100% was synthesized by a eight-step reaction of chlorination, bromination, benzylamine cyclization, hydrolysis, reduction, dehydration condensation, debenzylation hydrogenolysis and salt-forming. The structure was confirmed by 1 H NMR. |
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| Keywords: | adipic acid 3-oxa-8-azabicyclo [3. 2. 1] octane hydrochloride drug synthesis |
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