| 多组分光谱相关色谱及其在中药色谱指纺图谱分析中的应用 |
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| 引用本文： | 胡芸,梁逸曾,李博岩,徐承建,曾仲大.多组分光谱相关色谱及其在中药色谱指纺图谱分析中的应用[J].化学学报,2003,61(9):1466-1470. |
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| 作者姓名： | 胡芸 梁逸曾 李博岩 徐承建 曾仲大 |
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| 作者单位： | 中南大学化学化工学院,中药现代化研究中心,长沙,410083 |
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| 基金项目： | 国家自然科学基金 (Nos.2 0 2 350 2 0 ,2 0 1 750 36)重点资助项目 |
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| 摘 要： | 基于正交投影理论和相关色谱方法提出多组分光色谱方法提出多组分光谱相关 色谱。为克服联用色谱仪器的不等性噪声影响，采用目标组分投影前后的光谱夹角 余弦判据，判断不同的中药色谱指纹图谱的相关组分色谱峰簇。该方法为中药指纹 图谱的数据处理、合理评价以及中药谱效学的基本理论研究提供一种实用的工具。
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| 关 键 词： | 中药 色谱 指纹图谱 |
| 修稿时间： | 2003年1月7日 |
Multicomponent Spectral Correlative Chromatography Applied to Analysis of Chemical Fingerprints of Traditional Chinese Medicines |
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| Institution: | College of Chemistry and Chemical Engineering, Research Center of Modernization of Chinese Herbal Medicines, Central South University |
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| Abstract: | Multicomponent spectral correlative chromatography is proposed based on orthogonal projection and correlative chromatography. In order to eliminate the influence of heteroscedastic noise derived from hyphenated instruments, the cosine value of between target component spectrum and its projected residue is applied as a criterion to test the correlative component chromatographic clusters of different chemical fingerprints of traditional Chinese medicines (TCMs). This method provides a practical tool for data processing, reasonable evaluation of chemical fingerprints of TCMs, and the basic theoretical research on relationship between the chemical fingerprints of TCM and its pharmaceutical efficacy. |
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| Keywords: | characteristic chemical fingerprint of traditional Chinese medicine (TCM) cluster of chromatographic peaks hyphenated chromatography multicomponent spectral correlative chromatography orthogonal projection technique |
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