Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS |
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| Authors: | Elisana Afonso Moura Lidiane Pinto Correia Márcia Ferraz Pinto José Valdilânio Virgulino Procópio Fábio Santos de Souza Rui Oliveira Macedo |
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| Affiliation: | 1.Pharmaceutical Sciences Department,Federal University of Pernambuco—UFPE,Recife,Brazil;2.Unified Laboratories of Medicine Development and Assay—LUDEM,Federal University of Parahyba—UFPB,Jo?o Pessoa,Brazil |
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| Abstract: | This article had studied the thermal characterization of the raw material and different fluconazole crystals, obtained through recrystallization with different solvents using thermoanalytical techniques (TG, DTA, DSC-50, DSC Photovisual, DSC-60) and Pyr-GC/MS. The results confirmed that the fluconazole volatilizes without decomposition until 250 °C. Pyr-GC/MS showed hexachlorobenzene like impurities in fluconazole raw material. |
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