(1R,2R)-DPEN-derived triazolium salts for enantioselective oxodiene Diels-Alder reactions |
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| Authors: | Zi-Qiang RongMin-Qiang Jia Shu-Li You |
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| Affiliation: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China |
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| Abstract: | ![]()
Enantioselective oxodiene Diels-Alder reactions catalyzed by (1R,2R)-DPEN-derived triazolium salts were realized successfully. With 0.5 mol % of (1R,2R)-DPEN-derived triazolium salt C and 150 mol % of Et3N, the reactions of various α-chloroaldehydes (α-bromoaldehyde) with substituted enones led to 3,4-dihydropyridinones and their derivatives in good yields, diastereoselectivities, and enantioselectivities (up to 97% ee). |
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| Keywords: | Asymmetric catalysis (1R,2R)-DPEN Diels-Alder reactions N-Heterocyclic carbene Organocatalysis |
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