Intracellular spatial control of fluorescent magnetic nanoparticles |
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| Authors: | Gao Jinhao Zhang Wei Huang Pingbo Zhang Bei Zhang Xixiang Xu Bing |
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| Institution: | Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China. |
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| Abstract: | We report a facile intracellular manipulation of fluorescent magnetic Fe3O4-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe3O4 nanoparticles produces Fe3O4-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe3O4-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells. |
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